Tieteelliset julkaisut

Indoleamine Hallucinogens in Cluster Headache: Results of the Clusterbusters Medication Use Survey. (Schindler EA, Gottschalk CH, Weil MJ, Shapiro RE, Wright DA,.., 2015)
Julkaisu:Journal of Psychoactive Drugs
Tiivistelmä: Cluster headache is one of the most debilitating pain syndromes. A significant number of patients are refractory to conventional therapies. The Clusterbusters.org medication use survey sought to characterize the effects of both conventional and alternative medications used in cluster headache.

Participants were recruited from cluster headache websites and headache clinics. The final analysis included responses from 496 participants. The survey was modeled after previously published surveys and was available online. Most responses were chosen from a list, though others were free-texted. Conventional abortive and preventative medications were identified and their efficacies agreed with those previously published.

The indoleamine hallucinogens, psilocybin, lysergic acid diethylamide, and lysergic acid amide, were comparable to or more efficacious than most conventional medications. These agents were also perceived to shorten/abort a cluster period and bring chronic cluster headache into remission more so than conventional medications. Furthermore, infrequent and non-hallucinogenic doses were reported to be efficacious.

Findings provide additional evidence that several indoleamine hallucinogens are rated as effective in treating cluster headache.

These data reinforce the need for further investigation of the effects of these and related compounds in cluster headache under experimentally controlled settings.
Yhdiste:Psykedeelit yleisesti, LSD, psilosybiini
Aihe:Sarjoittainen päänsärky
Menetelmät:Kysely
Otoskoko:496
Muuta:
Tagit:
DOI:10.1080/02791072.2015.1107664
URL: https://www.ncbi.nlm.nih.gov/pubmed/26595349
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