Tieteelliset julkaisut

Psilocybin with psychological support for treatment-resistant depression: six-month follow-up. (Carhart-Harris RL, Bolstridge M, Day CMJ, Rucker J, Watts R,.., 2018)
Julkaisu:Psychopharmacology
Tiivistelmä: RATIONALE:
Recent clinical trials are reporting marked improvements in mental health outcomes with psychedelic drug-assisted psychotherapy.

OBJECTIVES:
Here, we report on safety and efficacy outcomes for up to 6 months in an open-label trial of psilocybin for treatment-resistant depression.

METHODS:
Twenty patients (six females) with (mostly) severe, unipolar, treatment-resistant major depression received two oral doses of psilocybin (10 and 25 mg, 7 days apart) in a supportive setting. Depressive symptoms were assessed from 1 week to 6 months post-treatment, with the self-rated QIDS-SR16 as the primary outcome measure.

RESULTS:
Treatment was generally well tolerated. Relative to baseline, marked reductions in depressive symptoms were observed for the first 5 weeks post-treatment (Cohen's d = 2.2 at week 1 and 2.3 at week 5, both p < 0.001); nine and four patients met the criteria for response and remission at week 5. Results remained positive at 3 and 6 months (Cohen's d = 1.5 and 1.4, respectively, both p < 0.001). No patients sought conventional antidepressant treatment within 5 weeks of psilocybin. Reductions in depressive symptoms at 5 weeks were predicted by the quality of the acute psychedelic experience.

CONCLUSIONS:
Although limited conclusions can be drawn about treatment efficacy from open-label trials, tolerability was good, effect sizes large and symptom improvements appeared rapidly after just two psilocybin treatment sessions and remained significant 6 months post-treatment in a treatment-resistant cohort. Psilocybin represents a promising paradigm for unresponsive depression that warrants further research in double-blind randomised control trials.
Yhdiste:Psilosybiini
Aihe:Masennus
Menetelmät:open label, seuranta
Otoskoko:20
Muuta:Seurantatutkimus tutkimuksesta Carhart-Harris ym. (2016).
Tagit:
DOI:10.1007/s00213-017-4771-x
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813086/
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