Tieteelliset julkaisut

Tulokset kategoriasta aihe hakusanalla Sarjoittainen päänsärky. Takaisin

The use of illicit drugs as self-medication in the treatment of cluster headache: Results from an Italian online survey. (Di Lorenzo C, Coppola G, Di Lorenzo G, Bracaglia M, Rossi P,.., 2016)
Tiivistelmä: BACKGROUND:
Cluster headache (CH) patients often receive unsatisfactory treatment and may explore illicit substances as alternatives. We aimed to explore this use of illicit drugs for CH treatment.

We invited CH patients from an Internet-based self-help group to complete a questionnaire regarding their therapeutic use of illicit substances.

Of the 54 respondents, 29 were classified as chronic and 39 were drug-resistant cases. Fifty patients had previously tried subcutaneous sumatriptan, 40 had tried O2, and 48 had tried at least one prophylactic treatment. All 54 patients specified that they were dissatisfied with conventional treatments. Thirty-four patients had used cannabinoids, 13 cocaine, 8 heroin, 18 psilocybin, 12 lysergic acid amide (LSA), and 4 lysergic acid diethylamide (LSD).

Some patients with intractable CH decided to try illicit drugs concomitantly with cessation of medical care. Most of these patients found suggestions for illicit drug use on the Internet. Many patients seemed to underestimate the judicial consequences of, and had an overestimated confidence in the safety of, such illicit treatments. Physicians are often not informed by patients of their choice to use illicit drugs. This leads to questions regarding the true nature of the physician-patient relationship among dissatisfied CH patients.
Yhdiste:LSD, psilosybiini
Aihe:Sarjoittainen päänsärky
URL: http://journals.sagepub.com/doi/abs/10.1177/0333102415583145

Indoleamine Hallucinogens in Cluster Headache: Results of the Clusterbusters Medication Use Survey. (Schindler EA, Gottschalk CH, Weil MJ, Shapiro RE, Wright DA,.., 2015)
Julkaisu:Journal of Psychoactive Drugs
Tiivistelmä: Cluster headache is one of the most debilitating pain syndromes. A significant number of patients are refractory to conventional therapies. The Clusterbusters.org medication use survey sought to characterize the effects of both conventional and alternative medications used in cluster headache.

Participants were recruited from cluster headache websites and headache clinics. The final analysis included responses from 496 participants. The survey was modeled after previously published surveys and was available online. Most responses were chosen from a list, though others were free-texted. Conventional abortive and preventative medications were identified and their efficacies agreed with those previously published.

The indoleamine hallucinogens, psilocybin, lysergic acid diethylamide, and lysergic acid amide, were comparable to or more efficacious than most conventional medications. These agents were also perceived to shorten/abort a cluster period and bring chronic cluster headache into remission more so than conventional medications. Furthermore, infrequent and non-hallucinogenic doses were reported to be efficacious.

Findings provide additional evidence that several indoleamine hallucinogens are rated as effective in treating cluster headache.

These data reinforce the need for further investigation of the effects of these and related compounds in cluster headache under experimentally controlled settings.
Yhdiste:Psykedeelit yleisesti, LSD, psilosybiini
Aihe:Sarjoittainen päänsärky
URL: https://www.ncbi.nlm.nih.gov/pubmed/26595349

Response of cluster headache to psilocybin and LSD. (Sewell RA, Halpern JH, Pope HG Jr., 2006)
Tiivistelmä: The authors interviewed 53 cluster headache patients who had used psilocybin or lysergic acid diethylamide (LSD) to treat their condition. Twenty-two of 26 psilocybin users reported that psilocybin aborted attacks; 25 of 48 psilocybin users and 7 of 8 LSD users reported cluster period termination; 18 of 19 psilocybin users and 4 of 5 LSD users reported remission period extension. Research on the effects of psilocybin and LSD on cluster headache may be warranted.
Yhdiste:LSD, psilosybiini
Aihe:Sarjoittainen päänsärky
URL: http://n.neurology.org/content/66/12/1920.long